Inhalation exposure system used for acute and repeated-dose methyl isocyanate exposures of laboratory animals.
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منابع مشابه
Inhalation exposure system used for acute and repeated-dose methyl isocyanate exposures of laboratory animals.
Laboratory animals were exposed by inhalation for 2 hr/day (acute) or 6 hr/day (four consecutive days, repeated dose) to methyl isocyanate (MIC). Exposures were conducted in stainless steel and glass inhalation exposure chambers placed in stainless steel, wire mesh cages. MIC was delivered with nitrogen via stainless steel and Teflon supply lines. Chamber concentrations ranged from 0 to 60 ppm ...
متن کاملInhalation exposure of animals.
Relative advantages and disadvantages and important design criteria for various exposure methods are presented. Five types of exposures are discussed: whole-body chambers, head-only exposures, nose or mouth-only methods, lung-only exposures, and partial-lung exposures. Design considerations covered include: air cleaning and conditioning; construction materials; losses of exposure materials; eve...
متن کاملMethyl isocyanate exposure and atypical lymphocytes.
December 3, 1984 marks one of the deadliest chemical disasters of the world took place in Bhopal. The disaster took a toll of 3600 human lives and scores of pets almost instantly. Additional 200 000 people were exposed to the killer gas—methyl isocyanate and its intermediates—to varying degrees.1 Almost 27 years have gone by since occurrence of this tragic event, the health status of the affect...
متن کاملBiological effects of short-term, high-concentration exposure to methyl isocyanate. I. Study objectives and inhalation exposure design.
Early reports from India indicated that humans were dying within minutes to a few hours from exposure to methyl isocyanate (MIC). Attempts to explain the cause(s) of these rapid mortalities is where Union Carbide Corporation concentrated its post-Bhopal toxicologic investigations. The MIC studies involving rats and guinea pigs focused primarily on the consequences of acute pulmonary damage. All...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1987
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.877245